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通过在质母细胞瘤中酸化HMGA1a,IKBKE促进了ZEB2介导的EMT过程

Yan Sun1, Gaochao Guo2, Yu Zhang3

  • 1Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China; Department of Neurosurgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong 264000, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China.

Cellular signalling
|January 19, 2024
PubMed
概括

核因子卡帕-B激酶子单元Epsilon (IKBKE) 抑制剂通过激活高流动性组AT-hook 1a (HMGA1a) 来促进质母细胞瘤,这反过来又提高了指E-box绑定homeobox 2 (ZEB2) 的调节. 这种IKBKE/HMGA1a/ZEB2通路驱动瘤的进展.

关键词:
在EMT中,EMT是EMT.在GBMGBMGBMGBMGBM这就是HMGA1a.这就是 IKBKE IKBKE.在ZEB2中,它是ZEB2.

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