来自Artemisia scoparia的二烯基化类反体
Guziliayi Kuerban1, Ablajan Turak2, Jiangyu Zhao1
1State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and the Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Phytochemistry
|January 19, 2024
概括
从Artemisia scoparia中分离了6种新的二烯化类反体和2种cis-trans异构体对. 一些化合物在基于细胞的测试中表现出适度的抗炎活性.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿尔特梅西 (Artemisia scoparia) 是一种具有丰富使用历史的药用植物.
- 了解其化学成分对于识别生物活性化合物至关重要.
- 以前的研究已经确定了各种化合物,但需要进一步调查.
研究的目的:
- 从Artemisia scoparia中分离和描述新的化学成分.
- 为了评估分离的化合物的抗炎潜力.
主要方法:
- 使用染色体和光谱技术 (1D,2D-NMR,HRESIMS) 的植物化学研究.
- 通过电子圆二极化 (ECD) 光谱学确定绝对配置.
- 在RAW264.7细胞中使用脂多糖糖诱导的氧化产生的体外抗炎试验.
主要成果:
- 分离了6对未经描述的二烯化类反体 (scopacoumaricin A-F) 和2对 cis-trans 同体 (cis/trans-scopacoumaricin G,cis/trans-artepillin A) 的物质.
- 首次从这个植物中报告了Trans-artepillin A.
- (-) - 斯科帕库马里辛D, (+) - 斯科帕库马里辛F和cis-斯科帕库马里辛G表现出适度的抗炎活性.
结论:
- 这项研究扩大了对Artemisia scoparia化学多样性的知识.
- 特定的分离化合物,包括scopacoumaricin反体和异体,具有抗炎性质.
- 这些发现表明Artemisia scoparia衍生物在治疗炎症方面的潜在治疗应用.
相关概念视频
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons
1.8K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
1.8K
Naming Enantiomers
20.4K
The naming of enantiomers employs the Cahn–Ingold–Prelog rules that involve assigning priorities to different substituent groups at a chiral center. Each enantiomer, being a distinct molecule, is assigned a unique name by the Cahn–Ingold–Prelog (CIP) rules, also called the R–S system. The prefix R- or S- attached to the chiral centers in an enantiomer is dependent on the spatial arrangement of the four substituents on the chiral center. The R–S system...
20.4K
Prochirality
3.8K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
3.8K
Racemic Mixtures and the Resolution of Enantiomers
18.4K
A racemic mixture, or racemate, is an equimolar mixture of enantiomers of a molecule that can be separated using their unique interaction with chiral molecules or media. Racemic mixtures are denoted by the (±)- prefix. This ‘optical rotation descriptor’ applies to the whole solution of a racemic mixture rather than a specific stereoisomer. Enantiomers typically have the same physical and chemical properties. Hence, they are not easily separable. However, enantiomers can exhibit...
18.4K
Sharpless Epoxidation
4.0K
The conversion of allylic alcohols into epoxides using the chiral catalyst was discovered by K. Barry Sharpless and is known as Sharpless epoxidation. The use of a chiral catalyst enables the formation of one enantiomer of the product in excess. This chiral catalyst is mainly a chiral complex of titanium tetraisopropoxide and tartrate ester (specific stereoisomer). The stereoisomer used in the chiral catalyst dictates the formation of the enantiomer of the product. In other words, the use of...
4.0K
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)
3.8K
Nucleophilic substitution in aromatic compounds is feasible in substrates bearing strong electron-withdrawing substituents positioned ortho or para to the leaving group. The reaction proceeds via two steps: the addition of the nucleophile and the elimination of the leaving group.
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...
3.8K

![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
