在注射药物的人群中,最佳的型肝炎C治疗坚持模式和持续的病毒学反应:HERO研究
Moonseong Heo1, Brianna L Norton2, Irene Pericot-Valverde3
1Department of Public Health Sciences, Clemson University, Clemson, SC 29605, USA.
Journal of hepatology
|January 19, 2024
概括
在注射药物 (PWID) 用直接作用抗病毒药物 (DAA) 治疗C型肝炎病毒 (HCV) 的人群中,高持续性病毒反应 (SVR) 率是可以实现的,即使附着性低于最佳水平. 尽量减少治疗中断和早期中止是成功治愈HCV的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 直接作用抗病毒药物 (DAA) 在治疗C型肝炎病毒 (HCV) 感染方面表现出高效.
- 了解注射药物使用者 (PWID) 的坚持模式对于优化治疗结果至关重要.
- 关于PWID中粘附模式和持续病毒学反应 (SVR) 之间的关联存在有限的数据.
研究的目的:
- 调查PWID中DAA的各种坚持模式.
- 为了确定不同粘附模式和SVR率之间的关联.
- 为了确定与>90%的SVR率相关的坚持值.
主要方法:
- 使用电子泡包来监测活跃PWID的12周内每天一次的索福斯布维尔/韦尔帕塔斯维尔的每日坚持.
- 分析了496名已知SVR状态的参与者的坚持数据.
- 量化坚持模式,包括总坚持日数,连续错过日数和早期停药.
主要成果:
- 实现了总体SVR率为92.7%,平均坚持率为75%.
- 表明较大的坚持的坚持模式与SVR有显著的关联.
- 具有≥50%的坚持日或<26个连续错过日的参与者群体实现了>90%的SVR. 早期停药和长时间的治疗中断与较低的SVR率有关.
结论:
- 高SVR率可以在PWID与HCV中实现,即使对DAA的遵守率低于最佳.
- 鼓励最大限度的药物摄入量,将连续遗漏日减少到<2周,并避免早期停药对于实现SVR至关重要.
- 这些发现对患者,临床医生,指南制定者和参与HCV治疗的付款人来说都很重要.
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