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Updated: Aug 13, 2026

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微质核受体核心压缩剂1缺乏缓解了小鼠的神经炎症

Shuqin Qiu1, Zihong Xian1, Junyu Chen2

  • 1NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Neuroscience letters
|January 19, 2024
PubMed
概括

核受体核心抑制剂1 (NCoR1) 缺乏通过增加PGC-1α表达来减少神经炎症. 这一发现为涉及炎症的神经退行性疾病提供了潜在的治疗点.

关键词:
在LPS中使用LPS.微质细胞中的微质细胞没有NCoR1的情况.它们是PGC-1α.

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NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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The heterodimer of NF-κB...