过敏状况与COVID-19易感性和结果之间的关联
Chao Chen1, Xue Song1, Dana J Murdock1
1Regeneron Pharmaceuticals, Inc., Tarrytown, New York.
概括
患有过敏症的人患COVID-19的风险更高,但感染后死亡率降低. 喘特别增加了COVID-19诊断后住院的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 2型炎症,免疫反应和COVID-19易感性之间的相互作用仍然不完全理解.
- 过敏状况,以2型炎症为特征,可能会影响COVID-19的结果.
研究的目的:
- 调查主要过敏状况与COVID-19感染风险之间的联系.
- 评估过敏状况对COVID-19相关住院和死亡率的影响.
主要方法:
- 使用Optum数据库进行的一项大型队列研究确定了患有或没有主要过敏症的成年患者 (喘,亚托皮炎,过敏性鼻炎,食物过敏,过敏症,性食道炎).
- 计算了COVID-19的发病率比率,比较了有和没有过敏症的患者,以及严重与非严重的喘/皮炎的患者.
- 调整后的危险比率估计为30天的COVID-19相关住院治疗和感染患者的全因死亡率.
主要成果:
- 过敏状况与COVID-19发病率增加22%有关 (IRR,1.22 [1.21-1.24]).
- 在COVID-19患者中,过敏状况对住院的影响很小 (aHR,0.96 [0.95-0.98]),但与20%的死亡率降低有关 (aHR,0.80 [0.78-0.83]).
- 与其他过敏状况相比,喘与更高的COVID-19住院和死亡风险有关 (aHR,1.27 [1.25-1.30]).
结论:
- 过敏状况与COVID-19诊断的风险增加有关.
- 尽管感染风险较高,但过敏状况似乎减少了COVID-19感染后的死亡率.
- 喘管理至关重要,因为它与较差的COVID-19结果有关,主要是由于住院治疗增加.
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