对暴露于的个体的死亡率和功能进行系统审查和元分析
Andrew M Horvit1, Donald A Molony2
1McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Environmental research
|January 19, 2024
概括
暴露可能不会增加职业环境中的死亡风险,可能是由于健康工人效应. 功能生物标志物数据有限,这表明需要在社区人口中进行更多的研究.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 职业健康 职业健康 职业健康
背景情况:
- 人类接触 (U) 发生在各种应用中,现有研究表明潜在的U诱导毒性.
- 之前对人类U暴露数据的统计综合是有限的范围和被考虑的暴露类型.
- 这项研究系统地评估了暴露于的人群中的与有关的死亡率和功能.
研究的目的:
- 在暴露于的人群中系统评估与有关的死亡率.
- 扩展现有的元分析,包括多种不同的暴露场景.
- 评估暴露对功能和损伤生物标志物的影响.
主要方法:
- 系统审查已出版和灰色文献.
- 包括报告暴露人类癌,炎/缩和其他相关疾病的死亡率的研究.
- 确定报告暴露对象与对照对象生物标志物测量的研究.
主要成果:
- 对36项研究的分析显示,癌 (SMR 0.93) 或慢性炎/症 (SMR 0.82) 的死亡率没有显著增加.
- 其他评估的临床结果也显示暴露个体的死亡率缺陷.
- 生物标志物分析表明,暴露和对照组之间的功能没有显著差异,受限于小样本大小.
结论:
- 观察到的死亡率赤字很可能归因于健康工人效应,因为大多数研究都涉及职业暴露.
- 由于研究数量少,样本大小小小,对脏生物标志物的分析受到精度低的限制.
- 未来的研究应该专注于社区人口,以评估慢性暴露对病进展的长期影响.
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