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mTORC1通路的翻译后调节:一个调节新陈代谢相关基因表达的开关

Yitao Wang¹, Tobias Engel², Xinchen Teng³

¹College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin D02 YN77, Ireland.

Biochimica et biophysica acta. Gene regulatory mechanisms

|January 19, 2024

概括

拉巴胺素复合体1 (mTORC1) 途径的机械性标调节细胞生长. 翻译后的修改,如酸化和无处不在影响mTORC1信号,为疾病和潜在疗法提供了洞察力.

科学领域:

细胞生物学细胞生物学
分子生物学分子生物学
生物化学生物化学

背景情况:

拉巴胺素复合体1 (mTORC1) 的机械性标是细胞生长的中心调节者,对营养素,生长因子和能量状态作出反应.
mTORC1的活动对合成代谢过程至关重要;它的抑制促进了在压力期间的代谢和细胞存活.
异常的mTORC1信号与各种疾病有关,包括癌症和代谢和神经退行性疾病.

研究的目的:

本综述阐明了翻译后修改 (PTM) 如何调节mTORC1信号通路.
它特别研究了酸化和无化在调节mTORC1活动中的作用.
该审查旨在将这些PTM与疾病发病和治疗策略联系起来.

主要方法:

本综述综合了关于mTORC1信号的现有文献.
它的重点是研究酸化和无化对mTORC1组件的影响.
该分析整合了与疾病机制和潜在药物点相关的发现.

主要成果:

酸化和无处不在是关键的PTM,可以动态控制mTORC1复杂的组装,定位和活动.
在mTORC1组件上的特定酸化位影响其与上游激活器和下游效应器的相互作用.
乌比基化可以针对mTORC1组件进行降解或改变其信号功能.

结论:

翻译后的修改,特别是酸化和无处不在,是mTORC1信号的关键调节者.
了解这些修改,可以对由mTORC1失调驱动的疾病有机学的见解.
针对mTORC1相关的PTMs代表了癌症和其他mTORC1相关病理的有前途的治疗途径.

关键词:

酸化是指酸化的方法.转录因子是一种转录因子.在Ubiquitination中使用.在mTOROR中使用mTOR.在mTORC1信号通道上.

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