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ATAD3突变体中胆固醇升高是一种补偿机制,导致膜胆固醇聚合

Mikel Muñoz-Oreja1,2,3, Abigail Sandoval4, Ove Bruland5

  • 1Department of Neurosciences, Biogipuzkoa Health Research Institute, 20014 San Sebastian, Spain.

Brain : a journal of neurology
|January 19, 2024
PubMed
概括

病态的ATAD3变体破坏胆固醇代谢,导致神经问题和扩大的溶酶体. 胆固醇升高可能会提供一些保护,但会导致有害的膜聚合物.

关键词:
在AAA+ ATPase中.ATAD3 ATAD3 ATAD3 是一个胆固醇疾病 胆固醇疾病溶酶体储存障碍 溶酶体储存障碍溶解体是溶解体的组成部分.线粒体疾病是线粒体疾病.

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