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侵蚀性手关节炎和肉症:来自骨关节炎倡议队列的数据
Kamyar Moradi1, Robert M Kwee1,2, Bahram Mohajer1
1Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
侵蚀性手关节炎 (EHOA) 与大腿肌肉构成的恶化有关,这表明肉,但仅在没有膝关节关节炎的个体中. 这表明潜在的系统因素影响老年人肌肉健康.
科学领域:
- 类风湿病学 类风湿病学
- 老年学是指老年学的学科.
- 肌肉骨健康 肌肉骨健康
背景情况:
- 骨关节炎 (OA) 是一种普遍的关节疾病,特别是在老年人中.
- 侵蚀性手部OA (EHOA) 是手部OA的一个特定亚型.
- 随着年龄的增长而导致的肌肉损失萨尔科佩尼亚是老年人的重大健康问题.
研究的目的:
- 为了调查EHOA和肉症之间的关联.
- 探索EHOA和没有EHOA的个体中大腿肌肉组成的变化.
- 为了确定是否同时存在的膝关节OA会影响EHOA和肉症之间的关系.
主要方法:
- 利用骨关节炎倡议队列,比较EHOA患者与倾向性得分匹配的非EHOA对照.
- 用MRI和深度学习在4年内测量大腿肌肉肌肉内脂肪组织 (intra-MAT) 和收缩区域.
- 基于膝盖OA (KOA) 的存在或不存在的分层分析.
主要成果:
- 在4年内,EHOA与增加的MAT内部沉积和减少四头肌收缩面积有关.
- 这些不良的肌肉组成变化仅在没有同时发生膝关节OA的参与者中观察到.
- 这项研究调整了对67.1±7.5岁参与者的844个大腿的分析中的潜在混因素.
结论:
- 侵蚀性手部OA与没有膝盖OA的个体的大腿肌肉质量逐渐恶化有关.
- 这一发现表明,可能存在连接EHOA和肉症的系统性途径.
- 需要进一步的研究来阐明这些系统性因素,并探索对萨尔科佩尼亚可修改方面的潜在干预措施.
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