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通过选择性准表达状感官神经元的angiotensin受体来缓解高血压

Caitlin Baumer-Harrison^1,2,3,4, Khalid Elsaafien^2,5,6, Dominique N Johnson^2,5,6

¹Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida 32611.

The Journal of neuroscience : the official journal of the Society for Neuroscience

|January 19, 2024

概括

结节中的表达血管素1a型受体的神经元充当气体受体,影响血压. 这些神经元对于心血管平衡至关重要,并可能为治疗高血压提供点.

科学领域:

神经科学是一个神经科学.
心血管生理学心血管生理学
分子生物学分子生物学

背景情况:

心血管平衡依赖于来自动脉巴罗受体的神经信号.
特定的神经元表达血管素类型-1a受体 (NG^AT1aR) 在巴罗感受中的作用仍然不清楚.

研究的目的:

为了调查表达血管素类型-1a受体 (NG^AT1aR) 的结节腺神经元是否作为巴罗受体起作用.
为了确定NG^AT1aR是否对雄性和雌性小鼠的血压有不同的影响.
阐明NG^AT1aR的神经解剖学和功能性质.

主要方法:

使用克里小鼠和克里依赖的AAV用于神经解剖学追踪 (tdTomato).
采用GCaMP6s的双光子静脉成像来监测神经元活动,以应对血压变化.
使用光遗传学 (通道罗多普辛-2) 刺激NG^AT1aR并评估心血管反应.
在正常血压和高血压 (DOCA-盐,血管素II) 两种小鼠模型中研究的反应.

主要成果:

NG^AT1aR从大动脉门接收输入,投射到NTS,并表达机械敏感通道Piezo1/2.
NG^AT1aR发射随着血压升高而增加.
对NG^AT1aR的光学刺激会引起血压和心率的频率依赖性下降.
高血压模型 (DOCA-盐,血管素II) 显示出改变或延迟的反应,这表明巴罗反射功能受损.

结论:

NG^AT1aR作为巴罗受体起作用,整合了血管机械感应和血管素信号传递.
这些神经元对于调节血压和心率至关重要.
功能障碍的NG^AT1aR信号可能会导致高血压,呈现出潜在的治疗点.

关键词:

这是一个自主化的自主性.酒吧感受器是一种感受器.这是一种巴罗反射.血压血压血压血压这就是Nodose nodose的意思.这是一个模糊的Vagus.

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