相关实验视频
Updated: Jul 5, 2025

10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
10.0K
扩散大B细胞淋巴瘤的流行病学和病因学
1City of Hope Comprehensive Cancer Center, Duarte, CA.
Seminars in hematology
|January 19, 2024
概括
扩散性大B细胞淋巴瘤 (DLBCL) 是最常见的非霍奇金淋巴瘤. 风险因素包括免疫缺陷,自身免疫性疾病,病毒感染,肥胖,家族病史和环境暴露,但仍有许多无法解释的因素.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是非霍奇金淋巴瘤 (NHL) 最常见的亚型,占全球所有NHL病例的三分之一.
- DLBCL发病率因国家而异,美国的年龄标准化率为每10万人7.2,通常随着年龄的增长而上升,男性和非西班牙裔白人更高.
- 虽然DLBCL的发病率在一些地区停滞不前,但在亚洲正在上升,并且由于人口老龄化,预计在发达国家会增加.
研究的目的:
- 总结目前对分散型大B细胞淋巴瘤 (DLBCL) 发病率,风险因素和病因贡献的理解.
- 突出需要在不同人群中进行更广泛的研究,以开发有效的预防和风险预测模型.
主要方法:
- 对DLBCL发病率模式的全球和美国癌症注册数据的审查.
- 综合已确定的风险因素,包括免疫状况,自身免疫状况,病毒感染,肥胖,遗传和环境暴露.
- 分析最近的病因洞察力和剩余的知识差距.
主要成果:
- DLBCL发病率受到年龄,性别,种族/种族和地理位置的影响.
- 确定的危险因素包括严重的免疫缺陷 (艾滋病毒/艾滋病,移植接受者),慢性免疫失调 (自身免疫性疾病,HIV,HCV,EBV,HBV等病毒感染),肥胖,家族病史和环境暴露 (杀虫剂,,三乙烯,草甘).
- 据估计,肥胖导致近四分之一的DLBCL病例,但大多数DLBCL病因仍然无法解释.
结论:
- 了解宿主和环境因素对于DLBCL病因至关重要.
- 为了开发临床相关的风险预测模型,跨多元种族和民族群体的进一步研究至关重要.
- 需要共同努力,制定有效的DLBCL预防策略.
更多相关视频
15:07VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
26.7K
10:18From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
13.7K
相关概念视频
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
The Intrinsic Apoptotic Pathway
6.6K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.6K
Cells of the Adaptive Immune Response
989
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
989
Disorders of Leukocytes
956
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
956
Pulmonary Tuberculosis II
239
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
239