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Updated: Jul 5, 2025

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使用rROMA从omics数据中表示和量化模块活动

Matthieu Najm1,2,3, Matthieu Cornet1,2,3, Luca Albergante1,2,3

  • 1INSERM U900, 75428, Paris, France.

NPJ systems biology and applications
|January 19, 2024
PubMed
概括

新的rROMA软件包有效地从高通量生物数据中分析基因组活动. 它有助于理解复杂的疾病,如囊性纤维化,通过识别活跃的信号通路和潜在的疾病机制.

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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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