在轻度的COVID-19后,微观结构性脑部异常,疲劳和认知功能障碍
Lucas Scardua-Silva1,2, Beatriz Amorim da Costa1,2, Ítalo Karmann Aventurato1,2
1Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), University of Campinas, Campinas, Brazil.
Scientific reports
|January 19, 2024
概括
轻度COVID-19幸存者表现出持续的认知问题和微妙的白质变化,即使没有焦虑或抑郁. 进一步的研究将确定这些大脑变化是暂时的还是永久的.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 后COVID-19条件可以包括神经成像和神经心理变化.
- 在轻度的COVID-19病例中,神经成像和神经心理学的联合研究有限.
研究的目的:
- 研究轻度COVID-19患者的认知功能障碍和大脑变化.
- 评估后轻度COVID-19患者的白质完整性和功能连接性.
主要方法:
- 对97个轻度感染的个体和77个对照的横截面研究.
- 使用3T-MRI与扩散张力成像 (DTI) 和静止状态功能性MRI (RS-fMRI).
- 包括半结构面试,神经学检查和神经心理评估.
主要成果:
- 患者报告记忆力丧失,疲劳和头痛.
- 确认疲劳,过度昏昏欲睡,言语流性和记忆力受损.
- 与对照组相比,DTI在COVID-19后患者的白质中显示出较高的轴向扩散性.
- 在后带带皮层功能连接方面没有发现显著差异.
结论:
- 轻微的COVID-19可以导致持续的认知障碍和微妙的白质异常.
- 在认知缺陷和神经成像发现之间没有发现相关性.
- 需要进行纵向研究来确定这些变化的持久性.
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