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在轻度的COVID-19后,微观结构性脑部异常,疲劳和认知功能障碍.

Lucas Scardua-Silva1,2, Beatriz Amorim da Costa1,2, Ítalo Karmann Aventurato1,2

  • 1Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), University of Campinas, Campinas, Brazil.

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概括

轻度COVID-19幸存者表现出持续的认知问题和微妙的白质变化,即使没有焦虑或抑郁. 进一步的研究将确定这些大脑变化是暂时的还是永久的.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 放射学 放射学是一门学科.

背景情况:

  • 后COVID-19条件可以包括神经成像和神经心理变化.
  • 在轻度的COVID-19病例中,神经成像和神经心理学的联合研究有限.

研究的目的:

  • 研究轻度COVID-19患者的认知功能障碍和大脑变化.
  • 评估后轻度COVID-19患者的白质完整性和功能连接性.

主要方法:

  • 对97个轻度感染的个体和77个对照的横截面研究.
  • 使用3T-MRI与扩散张力成像 (DTI) 和静止状态功能性MRI (RS-fMRI).
  • 包括半结构面试,神经学检查和神经心理评估.

主要成果:

  • 患者报告记忆力丧失,疲劳和头痛.
  • 确认疲劳,过度昏昏欲睡,言语流性和记忆力受损.
  • 与对照组相比,DTI在COVID-19后患者的白质中显示出较高的轴向扩散性.
  • 在后带带皮层功能连接方面没有发现显著差异.

结论:

  • 轻微的COVID-19可以导致持续的认知障碍和微妙的白质异常.
  • 在认知缺陷和神经成像发现之间没有发现相关性.
  • 需要进行纵向研究来确定这些变化的持久性.