Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

117
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
117
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

57
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
57
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

657
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
657
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

57
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
57
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

93
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
93

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Shifting From Systemic to Precision-Targeted Complement Therapies: Opportunities and Hurdles.

European journal of immunology·2026
Same author

In vivo evidence of effective complement modulation by TriFu in comparison to C5 inhibition and complement depletion.

Blood advances·2026
Same author

Systemic stress states are reversed by NPBWR1 inhibition.

bioRxiv : the preprint server for biology·2026
Same author

The Cellular Response Capacity as Diagnostic Head Start in Neutrophil Endotoxemia Sensing.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Microbial Legacy: Mycobacterium vaccae ATCC 15483<sup>T</sup> intergenerationally diversifies the microbiome and enhances stress resilience in male mice.

Molecular psychiatry·2026
Same author

A host defense role for Fibrinogen by direct binding of Clostridium botulinum C2 toxin.

Cellular and molecular life sciences : CMLS·2026

相关实验视频

Updated: Jul 5, 2025

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

6.4K

溶性终端补充复合体血液水平在精神分裂症中升高.

Susa Savukoski1, Marco Mannes1, Lisa Wohlgemuth1

  • 1Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm, University of Ulm, Ulm, Germany.

European archives of psychiatry and clinical neuroscience
|January 19, 2024
PubMed
概括

精神分裂症患者的终端补充复合体 (sTCC) 水平较高,表明慢性免疫激活. 这种补充标记物,sTCC,可以作为精神分裂症的特征标记物,与急性症状或治疗效应不同.

关键词:
C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4在C5a中,它是C5a.经典的路径路径.补充系统的补充系统.混器可以引起混.第一个情节精神病的精神病.sTCCCC 是一个很棒的项目.

更多相关视频

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.4K

相关实验视频

Last Updated: Jul 5, 2025

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

6.4K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.4K

科学领域:

  • 神经免疫学 神经免疫学
  • 补充系统生物学 补充系统生物学
  • 精神病学研究 精神病学研究

背景情况:

  • 由于疾病的异质性和研究设计的多样性,补充系统在精神分裂症 (Sz) 中的作用仍然不清楚.
  • 之前的研究对Sz患者的补充激活产生了不确定的发现.

研究的目的:

  • 与对照人群相比,对急性疾病,未接受药物治疗的 Sz 患者进行补充激活产品和经典通路功能研究.
  • 为了评估6周治疗后的变化,并探索与临床症状和炎症标志物的关联.

主要方法:

  • 酶相关免疫吸收试验 (ELISA) 用于测量96名Sz患者和96名对照者的终端补充复合物 (sTCC) 和C5a在血中的含量.
  • 分组分析包括血清中的C4成分和经典途径活性.
  • 调整等级转换 (ART) 模型被用来解释年龄和性别等共变量.

主要成果:

  • 在Sz患者和对照人群之间,在C5a,C4或经典通路功能方面没有发现显著差异.
  • 与对照组相比,Sz患者的血sTCC水平显著升高 (p=0.027).
  • 升高的sTCC与C反应蛋白 (CRP; p=0.006) 相关,但与临床症状严重程度或治疗反应无关.

结论:

  • 精神分裂症患者的sTCC升高表明在慢性,非特异性免疫激活中发挥作用,类似于CRP.
  • sTCC可能作为精神分裂症的特征标志物,反映出潜在的免疫失调.
  • 建议进行纵向研究,以了解精神病发展中的先天性免疫变化的时间动态.