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Updated: Jul 5, 2025

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

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复合异质合体MSH3生殖系变体和相关瘤体质DNA不匹配修复功能障碍

Minoru Koi1,2, Brandie H Leach3,4, Sarah McGee3,4

  • 1Division of Gastroenterology & Hepatology, Department of Internal Medicine, and Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.

NPJ precision oncology
|January 19, 2024
PubMed
概括

这项研究详细介绍了一名患有复合异质合体MSH3变体的患者,导致DNA修复发生改变,并可能对结肠癌的发展产生影响. 这些发现揭示了这些MSH3突变的生物学后果.

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