骨质发生不完善与心血管异常有关吗? 一个系统的文献审查
Sara J E Verdonk1,2,3, Silvia Storoni1,2,3, Dimitra Micha2,3,4,5
1Department of Endocrinology and Metabolism, Amsterdam UMC Location Vrije Universiteit, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Calcified tissue international
|January 19, 2024
概括
骨质发生不完美 (OI) 是一种影响原的遗传疾病,增加了心脏衰竭和心房动等心血管疾病的风险. 建议对所有OI患者进行早期心脏病学转诊.
科学领域:
- 遗传学和分子生物学
- 心血管医学 心血管医学
- 罕见疾病 罕见疾病
背景情况:
- 骨质变生不完美 (OI) 是一种罕见的遗传疾病,影响I型原,导致骨脆弱.
- 在OI患者中,越来越多地发现骨外表现,包括心血管疾病.
- 对OI的心血管异常缺乏研究,因此需要更大的临床意识.
研究的目的:
- 综合审查骨质发育不完善 (OI) 患者的心血管疾病.
- 提高人们对与OI相关的心血管风险的认识.
- 为OI患者提供临床指导方针和管理策略.
主要方法:
- 在PubMed,Embase,Web of Science和Scopus进行了系统的文献搜索.
- 包括从数据库创建到2023年4月的文章,遵守PRISMA指南.
- 专注于识别OI患者的心血管表现.
主要成果:
- 膜疾病,心力衰竭,心房动和高血压在OI患者中更为普遍.
- 与对照组相比,在OI患者中观察到更大的大动脉根直径.
- 心血管异常发生在所有OI类型和年龄组,包括儿童.
结论:
- 心血管疾病在患有 osteogenesis imperfecta 的个体中明显更为普遍.
- 这些发现支持了OI患者常规心脏病转诊的建议.
- 需要进一步进行纵向研究,以了解OI心血管异常的进展情况.
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