生物类似药在IBD中:每个临床医生需要知道的
Anthony Angyal1, Shubha Bhat2,3
1Department of Pharmacy, Cleveland Clinic Foundation, Cleveland, OH, USA.
Current gastroenterology reports
|January 19, 2024
概括
生物仿制药可为炎症性肠病 (IBD) 治疗节省成本,但吸收率较低. 解决对有效性和安全性的担忧可以改善获得这些重要生物疗法的机会.
科学领域:
- 胃肠病学 胃肠病学
- 药物经济学 药物经济学
- 免疫学 免疫学 免疫学
背景情况:
- 生物疗法对于炎症性肠病 (IBD) 管理至关重要,但与高成本有关.
- 生物类似药,即高度相似的生物产品,旨在减少医疗保健支出.
- 在IBD中生物仿制药的不足最佳吸收限制了潜在的成本节约和治疗机会.
研究的目的:
- 审查生物类似药的基本概念.
- 确定目前可用于IBD治疗的生物类似产品.
- 探索可以促进在IBD护理中增加生物类似药的利用的资源.
主要方法:
- 对生物类似概念和IBD治疗指南的文献综述.
- 对已批准的IBD生物类似产品 (infliximab,adalimumab,ustekinumab) 的分析.
- 检查报告的生物类似药采用障碍和克服这些障碍的策略.
主要成果:
- 生物类似药物为infliximab,adalimumab和ustekinumab已被批准用于IBD.
- 由于对疗效,安全性和进入市场的时间表的担忧,吸收率仍然很低.
- 证据表明,在IBD中,生物类似药和参考生物药之间具有可比的疗效和安全性.
结论:
- 生物类似药是一种有价值的策略,可以降低IBD的生物相关成本.
- 解决临床医生和患者的担忧对于提高生物类似药的利用至关重要.
- 利益相关者之间的协作努力是必要的,以最大限度地利用生物类似药在IBD治疗中的好处.
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