代谢综合征增加了骨关节炎的风险:来自英国生物银行前性队列研究的发现
Shiyong Zhang1, Danni Wang2,3, Jinyu Zhao4
1Department of Joint Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, Guangdong, China.
BMC public health
|January 19, 2024
概括
代谢综合征 (MetS) 和其组成部分,如中心肥胖和高血糖症,增加骨关节炎 (OA) 的风险. 管理MetS对于预防OA至关重要,特别是在高C反应蛋白 (CRP) 水平的情况下.
科学领域:
- 整形外科和运动医学
- 代谢和内分泌疾病 代谢和内分泌疾病
- 流行病学 流行病学
背景情况:
- 关于代谢综合征 (MetS) 和骨关节炎 (OA) 风险之间的关联,存在相互矛盾的证据.
- 了解这种联系对于制定有效的OA预防和管理策略至关重要.
研究的目的:
- 调查MetS,其各个组成部分和发展OA的风险之间的关联.
- 探索生活方式因素,药物,C反应蛋白 (CRP) 和多基因风险评分 (PRS) 对这种关联的影响.
主要方法:
- 一项使用英国生物库数据的前性队列研究.
- 根据国际糖尿病联合会 (IDF) 标准定义的MetS;用于风险评估的Cox比例危险回归.
- 使用了卡普兰-梅尔曲线,日志级别测试,限制立方线 (RCS) 和多基因风险评分 (PRS) 分析.
主要成果:
- MetS与15%的骨关节炎风险增加有关 (HR=1.15). 中心肥胖 (HR=1.58) 和高血糖 (HR=1.13) 显示出显著的关联.
- 脱脂症 (甘油三和高血糖) 与风险有轻微的关联.
- 在高CRP (HR=1.35) 个体中,MetS增加了OA风险35%;在MetS和PRS之间没有发现相互作用.
结论:
- 代谢综合征及其组成部分与骨关节炎风险增加有关.
- 升高的CRP水平在患有MetS的个体中放大了OA风险.
- 管理MetS是一种重要的骨关节炎预防和干预策略.
相关概念视频
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Obesity
505
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
505
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K


