在A型链球菌病谱中的状态转换:范围审查和证据差距
Prerana Parajulee1, Jung-Seok Lee2, Kaja Abbas3,4
1International Vaccine Institute, Seoul, Republic of Korea. prerana.parajulee@ivi.int.
BMC infectious diseases
|January 19, 2024
概括
菌株甲菌 (Strep A) 可以引起从表面到侵入性的疾病. 这次审查绘制了疾病过渡的地图,发现侵袭性疾病往往导致死亡,但低收入国家缺乏数据.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 菌株甲菌 (Strep A) 引起广泛的疾病,从轻微的侵袭性感染到危及生命的侵袭性感染.
- 了解疾病的进展和转变对于有效的管理和预防至关重要.
研究的目的:
- 综合了Streptococcus pyogenes引起的疾病状态过渡的证据.
- 识别了解A型链球菌病谱进展的差距.
主要方法:
- 从1980年到2021年发表的文章的范围审查.
- 确定了175篇文章,报告了262个不同的A型链球菌病态转变.
主要成果:
- 从侵袭性或毒素介导性疾病状态过渡到复发性急性类风湿性发烧 (ARF),类风湿性心脏病 (RHD) 或死亡是最常见的 (43.9%).
- 涉及局部侵入性疾病的转变是最少报告的 (0.02%).
- 经常报告从侵袭性疾病过渡到死亡 (n=71),而过渡到局部侵袭性疾病显著缺席.
结论:
- 这项研究强调了从侵袭性A型链球菌到死亡等严重结果的频繁过渡.
- 需要在低收入和中等收入国家进行研究,以了解在高负担环境中A型链球菌病谱的过渡.
- 需要对过渡到局部侵袭性疾病的进一步研究,以及诸如喉炎到侵袭性疾病的特定途径.
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