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在试管婴儿刺激期间,血清红素水平会增加,但在OHSS中不会增加

Merituuli Rekola¹, Kati Korhonen¹, Leila Unkila-Kallio¹

¹Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, PO Box 140, Haartmaninkatu 2, Helsinki, 00290, Finland.

Reproductive biology and endocrinology : RB&E

|January 19, 2024

概括

在体外受精 (IVF) 周期期间,红素 (Epo) 水平发生变化,随着刺激而增加,并随着怀孕结果而变化. 埃波不是卵巢过度刺激综合征 (OHSS) 的可靠标志物.

科学领域:

生殖内分泌学生殖内分泌学
血管生物学血管生物学
在体外受精过程中受精.

背景情况:

红色素 (Epo) 是一种参与血管生成和抗亡的生长因子.
在试管婴儿期间调查EPO在卵巢生理学中的作用至关重要.
评估EPO作为卵巢过度刺激综合征 (OHSS) 的潜在标志物是有必要的.

研究的目的:

为了确定Epo水平是否受到IVF期间的卵泡和红色体发育的影响.
评估EPO作为OHSS的潜在新生物标志物.
探索EPO,怀孕和试管婴儿结果之间的关系.

主要方法:

在接受无并发性试管婴儿的妇女中,循环中的EPO水平的比较分析与那些患有OHSS的妇女相比.
在血液样本中测量EPO,孕激素,血红蛋白和肌素.
卵泡液中Epo和孕的分析;与VEGF和HIF-1的相关性.

主要成果:

循环中的Epo水平在受刺激的试管婴儿周期中明显增加,相比于自然的质阶段.
根据卵细胞采集后的妊娠结果,EPO水平有所不同.
毛囊液Epo度高于血清Epo;在早期OHSS和无并发性试管婴儿组之间没有显著的Epo差异.

结论:

在整个试管婴儿周期中,循环的Epo水平呈现波动,这表明在卵巢生理学和血管生成中发挥了作用.
发现epo不是诊断OHSS的可靠临床标志物.
进一步的研究可能会阐明Epo在卵巢对刺激的反应中的特定功能.

关键词:

血管新生的产生.怀孕早期的怀孕时间红色素是人为的蛋白质.在试管婴儿受精体外受精.卵巢过度刺激综合征卵巢过度刺激综合征

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