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肠道微生物群的性别特异性与心血管疾病相关
Helena Garcia-Fernandez1,2,3, Antonio P Arenas-de Larriva1,2,3, Javier Lopez-Moreno1,2,3
1Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, Cordoba, Spain.
Biology of sex differences
|January 19, 2024
概括
肠道微生物群在患有冠状动脉心脏病 (CHD) 的男性和女性之间存在显著差异. 这些特定于性别的肠道细菌可能解释了为什么男性患心血管疾病 (CVD) 的比例更高.
科学领域:
- 微生物组研究 微生物组研究
- 心血管疾病流行病学
- 基于性别的生物差异
背景情况:
- 心血管疾病 (CVD),特别是冠心病 (CHD),在男性中比女性更为普遍.
- 了解导致这种性别差异的潜在生物学因素对于有针对性的预防和治疗策略至关重要.
研究的目的:
- 为了研究患有心血管疾病的个体肠道微生物群的性别特异性.
- 为了比较患有心血管疾病的男性和女性的肠道微生物群概况,与没有心血管疾病的性别匹配对照进行比较.
主要方法:
- 分析了来自CORDIOPREV研究的837名男性和165名患有心血管疾病的女性以及对照组 (270名男性,105名女性) 的16S元基因组学数据.
- 在Illumina MiSeq平台上使用Quiime2软件进行数据处理.
- 统计分析包括β多样性,α多样性,线性差异分析效果大小 (LEfSe) 和随机森林 (RF) 方法.
主要成果:
- 在患有心血管疾病的人群中,在肠道微生物群组成中观察到显著的性别特异性 (β多样性).
- 阿尔法多样性在两性之间保持一致.
- 七种细菌种群,包括Ruminococcaceae,Bilophila,Subdoligranulum,Phascolarctobacterium,Barnesiellaceae和Ruminococcus,被确定为CHD状态的关键歧视因素,具有性别特异性的改变.
结论:
- 这项研究表明,与心血管疾病相关的肠道微生物群的性别特异性失生症.
- 这些发现可能会阐明在男性中观察到的CVD的更高发病率.
- 对性别特异性微生物干预的进一步研究可能为心血管疾病预防和管理提供新的治疗途径.
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