相关实验视频
Updated: Aug 11, 2026
08:58
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
16.0K
肝硬化和乙型肝炎病毒的相关性分析:一个横截面研究
Sitong Yi1, Guanghui Ren1, Ying Zhu2
1Department of Infectious Disease and Liver Disease Center of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Virology journal
|January 19, 2024
概括
肝脂肪症或脂肪肝与慢性乙型肝炎 (CHB) 和MAFLD患者的乙型肝炎病毒 (HBV) 水平降低有关. 这一发现表明代谢功能障碍与HBV活性降低之间存在潜在联系.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 代谢疾病 代谢疾病
背景情况:
- 慢性乙型肝炎 (CHB) 和与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的同时发生越来越被认可.
- 了解这些条件之间的相互作用对于管理患者的结果至关重要.
研究的目的:
- 为了研究肝肥胖症和乙型肝炎病毒 (HBV) 感染之间的关联.
- 分析肝硬化如何影响CHB患者的HBV病毒学.
主要方法:
- 一项对272名CHB患者的横截面研究,分为CHB和CHB+MAFLD组.
- 对HBVDNA,HBsAg,HBeAg和pgRNA水平的分析.
- 使用多变量逻辑回归和斯皮尔曼相关性分析.
主要成果:
- 与CHB组相比,CHB+MAFLD患者的HBVDNA,HBsAg和HBeAg阳性率显著降低.
- 在肝硬化和pgRNA,HBV DNA,HBsAg和HBeAg水平之间观察到负相关性.
- HBV DNA,HBsAg和受控衰减参数 (CAP) 是影响pgRNA水平的独立因素.
结论:
- 肝硬化与乙型肝炎病毒学有负相关性.
- 患有CHB和MAFLD的患者表现出降低的HBV表达.
相关概念视频
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...