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Updated: Jun 19, 2026

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans
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虚拟双胞胎用于在治疗耐药精神分裂症患者中以模型为基础精确剂量克洛扎宾

Sam Mostafa1,2, Reza Rafizadeh3, Thomas M Polasek1,4,5

  • 1Centre for Medicine Use and Safety, Monash University, Parkville, Victoria, Australia.

CPT: pharmacometrics & systems pharmacology
|January 20, 2024
PubMed
概括

使用虚拟双胞胎 (MIPD-VTs) 进行基于模型的精确剂量测定,有望预测治疗耐药精神分裂症患者的克洛扎宾度. 虽然对许多人有效,但对药物相互作用的预测需要进一步细化,特别是对流胺.

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