洛卡因喷雾对接材料降解的影响
Pantea Jannati1, Charlotte Arp Sørensen2, Ditte Gommesen3
1Hospital Pharmacy Central Denmark Region, Clinical Pharmacy, Aarhus University Hospital, Aarhus N, Denmark.
概括
施洛卡因喷雾中的乙醇减弱了快速吸收的多聚黄素910,降低了拉伸强度. 建议在使用西洛卡因喷雾剂与这些合时谨慎使用,以防止早期破坏和潜在的伤口破裂.
科学领域:
- 手术材料科学 科研 科研
- 药理学 药理学是指药理学的学科.
- 生物材料是一种生物材料.
背景情况:
- 快速吸收的PolyGlactin 910 sutures通常用于外科手术.
- 当地麻醉喷雾,如西洛卡因喷雾,通常在手术期间应用.
- 麻醉剂对完整性的潜在影响尚未完全理解.
研究的目的:
- 为了比较 Polyglactin 910 的抗拉强度,在与各种剂物浸后进行接.
- 为了确定西洛卡因喷雾中的乙醇是否会降低线的抗拉强度.
- 为了研究使用Xylocaine喷雾与Polyglactin 910的临床影响.
主要方法:
- 120个多重银910接样本被分为四组.
- 群体被浸了化,西洛卡因喷雾剂,西洛卡因凝或乙醇.
- 针在37°C进行72小时的化,然后使用通用测试机测试拉伸强度.
主要成果:
- 用西洛卡因喷雾 (11.40 N) 和乙醇 (11.86 N) 处理的部显著降低了拉伸强度.
- 用西洛卡因凝 (13.81 N) 和化 (13.28 N) 处理的部保持了更高的抗拉强度.
- 在西洛卡因凝和西洛卡因喷雾组之间观察到显著差异 (P < 0.001).
结论:
- 乙醇和西洛卡因喷雾显著削弱了快速吸收的多聚黄素910的抗拉强度.
- 洛卡因喷雾中的乙醇含量可能会导致早期线材料的分解.
- 建议在使用西洛卡因喷雾剂与波利格拉910合时谨慎使用,以避免潜在的伤口并发症.
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