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Updated: Jul 5, 2025

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

Published on: January 29, 2019

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死亡盒酶1通过诱导肝细胞癌中的PD-L1表达来抑制CD8+T细胞抗瘤活性

Junhao Liu1, Ti Yang1,2, Yurong Luo1,2

  • 1Department of Hepatobiliary-Pancreatic & Hernia Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China.

Cancer science
|January 20, 2024
PubMed
概括

死亡盒螺旋酶1 (DDX1) 在肝细胞癌 (HCC) 中过度表达,通过增加PD-L1表达来促进免疫逃生. 这阻碍了CD8+ T细胞的功能,表明DDX1作为免疫检查点抑制剂治疗的生物标志物.

关键词:
死亡盒螺旋酶1的死亡盒.细胞毒性CD8+ T细胞细胞毒性肝细胞癌是肝细胞癌.免疫检查点抑制剂免疫检查点抑制剂

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