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Updated: Jul 5, 2025

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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scCancer2:在单一级分辨率下对瘤微环境的数据驱动深度注释.

Zeyu Chen1, Yuxin Miao1, Zhiyuan Tan2

  • 1MOE Key Laboratory of Bioinformatics, BNRIST Bioinformatics Division, Institute for Precision Medicine & Department of Automation, Tsinghua University, Beijing 100084, China.

Bioinformatics (Oxford, England)
|January 20, 2024
PubMed
概括

scCancer2可在瘤微环境中使用单细胞RNA测序 (scRNA-seq) 数据进行精确的细胞类型注释. 它集成了多个数据集,以绘制细胞亚型相似性的地图,并改善恶性细胞的识别.

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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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