叶酸支持在肠道病毒感染后的IL-25诱导的状细胞扩张
Ruining Lyu1, Jing Wu1, Yating He1
1Center for Public Health Research, Medical School, Nanjing University, Nanjing, China.
概括
叶酸新陈代谢支持肠道细胞在肠道病毒感染期间扩张,通过促进干白素25 (IL-25) 信号传递. 这突显了一种新的代谢途径,对于肠道中免疫细胞的增殖至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 代谢途径 代谢途径
背景情况:
- 肠细胞是关键的上皮免疫细胞,在感染期间扩大.
- 干白素25 (IL-25) 的上调与感染诱导的细胞扩张有关.
- 驱动IL-25介导的状细胞扩张的代谢机制尚不清楚.
研究的目的:
- 为了研究叶酸代谢在IL-25诱导的细胞扩张中的作用.
- 探索肠道病毒感染和重组性小鼠IL-25 (rmIL-25) 对细胞增殖和叶酸通路的影响.
主要方法:
- 使用的小鼠模型感染了肠道病毒 (EV71,CVA16,CVB3,CVB4) 或被rmIL-25.5刺激.
- 检查了肠道组织中的状细胞扩张和IL-25表达.
- 评估了叶酸枯竭和甲状腺酸盐 (MTX) 治疗对细胞扩张的影响.
主要成果:
- 肠道病毒在野生型小鼠中增加了IL-25的调节,并诱导了状细胞扩张,但在IL-25淘汰小鼠中没有.
- 感染和rmIL-25刺激小鼠的肠道中叶酸水平得到了丰富.
- 叶酸枯竭或MTX治疗损害了rmIL-25诱导的细胞扩张.
结论:
- 叶酸代谢对于IL-25诱导的肠细胞扩张至关重要.
- 肠道病毒诱导的IL-25依赖叶酸通路来促进细胞的增殖.
- 这项研究揭示了一种新的代谢机制,它是肠道免疫细胞扩张的基础.
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