在格鲁吉亚州本宁堡的初步军事训练期间口腔微生物组的动力学
Kristina K Zudock1, Robert Player2, Amanda Ernlund1
1Research and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA.
Military medicine
|January 20, 2024
概括
军事训练导致口腔微生物群的融合,增加感染风险. 这项研究跟踪了受训者的微生物组变化,发现截然不同的基线样本在第14天汇聚在一起,与Streptococcus增加相吻合. 类青素G (Bicillin) 并没有显著改变Streptococcus的丰富性.
科学领域:
- 微生物组研究的研究.
- 传染病流行病学 传染病流行病学
- 军事医学 军事医学
背景情况:
- 军事学员面临着由于密切接触和压力而增加的传染病风险.
- 标准的对策包括免疫接种和化学预防,如酸丁青素G (Bicillin).
- 这项研究调查了美国陆军步兵训练期间口腔微生物组的变化.
研究的目的:
- 评估军事学员口腔微生物组的变化.
- 评估比西林预防对口腔微生物群的影响.
- 在受控的培训环境中了解微生物组动态.
主要方法:
- 美国陆军步兵学员的观察队列研究 (2015-2016).
- 在多个时间点 (0-90天) 采集的口腔喉拭片.
- 使用QIIME 2和R.使用16S rRNA基因扩增序列和微生物组分析.
主要成果:
- 口腔微生物组在基线时是不同的,但在第14天显示出显著的趋同.
- 第14天的收与增加的链球菌DNA序列相关.
- 与2016年相比,2015年比西林的使用并没有显著改变整体链球菌的丰度.
结论:
- 在实习生中,口腔微生物群的短暂融合与传染性感染的增加相吻合.
- 在初始培训期间的微生物组动态反映了同居下的过渡性融合的发现.
- 这个群体为受控人类微生物组研究提供了一个模型.
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