人类Hsp70基质结合域识别不同的客户端蛋白质

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Updated: Jul 5, 2025

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
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In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells

Published on: September 2, 2019

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Andrew J Ambrose1, Christopher J Zerio1, Jared Sivinski1

  • 1Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, United States.

Biochemistry
|January 20, 2024
PubMed
概括

人类热冲击蛋白70 (Hsp70) 异型表现出明显的基质特异性,挑战J域含蛋白 (JDP) 作为多样性的唯一驱动因素的作用. 这一发现影响了癌症和神经退行性疾病的治疗策略.

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