狗的皮肤巨细胞症:一个多中心病例系列
Eleanor K Wyatt1, Verena Affolter2, Stefano Borio3
1Department of Small Animal Clinical Sciences, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Veterinary and comparative oncology
|January 20, 2024
概括
狗皮质巨细胞症 (CM) 是狗的罕见皮肤疾病,通常与皮肤上的人类巨细胞症 (MIS) 相似. 葡萄糖皮质类药物在治疗病变方面取得了成功,这表明了类似的疾病途径.
科学领域:
- 兽医皮肤病学 兽医皮肤病学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 狗的皮肤巨细胞瘤 (CM) 是罕见的,与狗的巨细胞瘤不同.
- 人类皮肤巨细胞瘤 (MIS) 常常影响儿童,并且可以自发消失.
- 人类的全身性巨细胞瘤 (SM),包括骨髓,通常影响成年人,预后可能不好.
研究的目的:
- 描述疑似MIS的狗的临床病理学发现,治疗和结果.
- 调查人类和犬类MIS之间的潜在相似之处.
- 在怀疑MIS的狗中分析KIT突变.
主要方法:
- 对11只可疑患有MIS的狗进行了回顾性审查,不包括那些患有多重巨细胞瘤的狗.
- 皮肤病变的组织病理学审查.
- 在8只狗中进行了KIT突变分析 (外显子8,9,11,14,17).
主要成果:
- 诊断时的平均年龄为4岁.
- 临床症状包括多焦点到普遍的结节和斑块.
- 在8只狗中的3只 (exon 9: 2; exon 11: 1) 检测到KIT突变.
- 一只狗呈现出巨细胞血症,表明可能的SM.
- 葡萄糖皮质类药物导致所有8只接受治疗的狗的病变改善.
结论:
- 狗的MIS与人类的MIS具有临床相似之处.
- 基因基因突变可能在犬类MIS中起作用.
- 需要进一步的研究来确定与MS相关的犬CM和MIS的诊断标准.
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