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儿童血清11氧化的参考间隔

Bas P H Adriaansen^1,2, Sandra E Oude Alink¹, Dorine W Swinkels¹

¹Radboud university medical centre, Department of Laboratory Medicine, Nijmegen, the Netherlands.

European journal of endocrinology

|January 20, 2024

概括

这项研究建立了儿童11-氧化的参考间隔. 这种新测试可以更好地诊断高雄性质,有助于临床管理诸如先天性上腺增生症等疾病.

科学领域:

内分泌学在内分泌学.
临床化学临床化学
儿科内分泌学儿科内分泌学

背景情况:

经典的雄激素常规测量用于儿童的高雄雄激素症诊断.
上腺衍生的11-氧化也对雄激素水平有所贡献,但缺乏儿科参考间隔.
这种差距阻碍了对儿科高雄性质症的全面评估.

研究的目的:

开发和验证一种血清测定方法,用于量化四种11-氧化雄激素以及四种经典雄激素.
为这八种雄激素建立儿科参考间隔.
为了改善儿童高雄性质症的临床评估.

主要方法:

开发并验证了一种敏感的液体染色学-并联质谱法 (LC-MS/MS) 试验.
分析了来自256名健康儿童 (0-17岁) 的血清样本.
对青春期前和青春期年龄组计算了参考间隔,考虑到观察到的年龄依赖性.

主要成果:

该试验成功量化了8种血清雌激素,包括4种11-氧化形式.
对于所有测量的雄激素,观察到与年龄相关的变化.
虽然一些经典的雄激素在青春期表现出性别差异,但11-氧化雄激素在青春期前或青春期组中都没有表现出显著的性别差异.

结论:

建立了对11-氧化雄激素和经典雄激素的验证试验.
这些雄激素的儿科参考间隔已经成功确定.
这项工作有助于更全面地评估儿科高雄性质症中雄激素状况.

关键词:

含有11氧的原体.色素是一种色素.过高雄性主义 (hyperandrogenism) 是一种高雄性主义.液态染色学串联质谱学质谱学参考时间间隔是参考时间间隔.

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