慢性便秘和刺激性肠综合征与消化道癌症的因果关系:孟德尔的随机化研究
Rencai Fan1, Jiaqi Zhang1, Jiaofeng Shen1
1Department of Oncology, The Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, Gusu District, Soochow 215004, Jiangsu Province, P.R. China.
Recent patents on anti-cancer drug discovery
|January 20, 2024
概括
便秘会增加胰腺癌的风险,刺激性肠综合征 (IBS) 与结直肠癌 (CRC) 的易感性有关. 这些疾病与其他消化道癌症之间的因果关系尚不清楚.
科学领域:
- 胃肠道学和瘤学
- 遗传流行病学遗传流行病学
背景情况:
- 慢性便秘和刺激性肠综合征 (IBS) 是常见的胃肠道疾病.
- 消化道癌症 (DTCs) 给全球健康带来了重大挑战.
- 现有研究对便秘,IBS和DTC风险之间的因果关系提供了有限的证据.
研究的目的:
- 调查便秘和IBS与七种DTC风险之间的潜在因果关系.
- 利用门德尔的随机化 (MR) 来评估这些关联.
主要方法:
- 孟德尔随机化 (MR) 分析是使用来自FinnGen数据库的遗传仪器变量 (IV) 进行的.
- 分析了七种DTC:结直肠癌 (CRC),肝细胞癌 (HCC),食道恶性瘤 (ESCA),胰腺腺癌 (PAAD),胆道癌 (BTC),胃癌 (GC) 和小肠瘤 (SIC).
- 使用了多种分析方法,包括IVW (MRE和FE),ML,WM,MR-Egger和MR-PRESSO.
主要成果:
- 基因预测的便秘与胰腺腺癌 (PAAD) 风险增加有显著的关联 (OR = 2.29).
- 基因预测IBS与异常值去除后结直肠癌 (CRC) (OR = 1.17) 的更高风险相关.
- 在便秘或IBS和其他DTC之间没有发现确的因果关系.
结论:
- 便秘与胰腺腺癌 (PAAD) 的风险增加有关.
- 刺激性肠综合征 (IBS) 与欧洲人口对结肠直肠癌 (CRC) 的易感性增加有关.
- 便秘,IBS和其他消化道癌症之间的因果关系需要进一步调查.
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