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控制在体内释放阿司匹林使用涂有点的ZIF-8纳米粒子

Fatemeh Shahidi¹, M Reza Naimi-Jamal¹, Azizollah Habibi²

¹Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, 16846-13114, Tehran, Iran.

Current drug delivery

|January 20, 2024

概括

这项研究开发了一种涂有pectin的ZIF-8金属有机框架,用于阿司匹林药物输送. 新型ZIF-8/Asp@Pectin平台展示了有效的阿司匹林加载和受控释放,展示了其在制药应用中的潜力.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

氧化伊米达酸框架 (ZIFs) 是重要的金属有机框架 (MOFs),以高表面积,可调节的毛孔和稳定性而闻名.
ZIF-8具有出色的热和化学稳定性,使其成为先进应用的有希望的材料.

研究的目的:

开发一种有效的药物输送系统,使用装载着阿司匹林并涂上丁的ZIF-8 (ZIF-8/Asp@Pectin).
调查ZIF-8/Asp@Pectin新型复合物的制备和表征.
从开发的药物输送平台评估阿司匹林的体外释放特征.

主要方法:

用阿司匹林装载的ZIF-8的环保合成.
将阿司匹林装载的ZIF-8涂上点,形成ZIF-8/Asp@Pectin.
使用X射线衍射 (XRD),SEM,TGA,FT-IR和BET分析进行全面的表征.
在实验室中使用UV-Vis光谱在模拟的胃 (HCl) 和肠 (PBS) 条件下进行药物释放研究.

主要成果:

成功合成并对ZIF-8/Asp@Pectin复合物的表征.
在ZIF-8结构中演示有效的阿司匹林加载.
鉴定证实了ZIF-8/Asp@Pectin材料的结构完整性和性能.
在体外研究提供了关于阿司匹林从药物输送系统释放动学的见解.

结论:

ZIF-8/Asp@Pectin作为一种可行的和有效的药物输送平台.
丁涂层确保了阿司匹林的稳定性和受控的释放.
开发的系统对未来的制药配方和应用具有前景.

关键词:

MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF 这里是ZIF-8的位置.在ZIF-8/Asp@Pectin.中使用.阿司匹林是一种阿司匹林.药物输送系统是药物输送系统.质素 (pectin) 是一种质素.

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