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在现实环境中对血管向光动力学治疗的随访
Angelika Borkowetz1,2, Jeremy Kwe3, Katharina Boehm3
1Department of Urology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. angelika.borkowetz@ukdd.de.
World journal of urology
|January 20, 2024
概括
针对血管的光动力学疗法 (VTP) 显示了低风险前列腺癌 (PCa) 的高复发率. 改善治疗前诊断对于减少瘤复发和VTP进展风险至关重要.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医疗技术 医疗技术 医学技术
背景情况:
- 针对血管的光动力学疗法 (VTP) 是对单边低风险前列腺癌 (PCa) 的一贯治疗方法.
- 对VTP的长期疗效和安全性的现实数据对于治疗指导至关重要.
研究的目的:
- 为了评估VTP的瘤和功能结果在一个现实世界的设置,为患者单方面低或中等风险的PCa.
- 为了评估复发率,进展,和功能维护后VTP hemiablation.
主要方法:
- 评估了一组患有单边低风险或中等风险PCa经历VTP半流血的患者队列.
- 在12个月和24个月后,通过基于MRI的再活检评估了瘤结局.
- 功能性结果 (勃起功能,膀出口阻塞) 使用IIEF-5和IPSS问卷进行了评估.
主要成果:
- 只有37%的患者在随访活检时没有癌症.
- 没有复发的生存期为20个月,没有进展的生存期为38.5个月.
- 现场 (37%) 和现场外 (35%) 复发率很高,ISUP等级≥2PCa的比例很高. 79%的患者保持了勃起功能,10%的患者经历了膀出口阻塞.
结论:
- 在一个主要是低风险前列腺癌患者的队列中,VTP表现出高的场内和场外复发率.
- 应该对这些患者的治疗选择进行批判性评估.
- 增强的介入前诊断评估对于减轻瘤复发和进展与焦点治疗相关的风险至关重要.
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