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在植入前遗传测试周期中,可从体外成熟的甲相I卵子中开发出可用的胚胎细胞

Yuehan Li¹, Lei Jin¹, Wenqu Tian¹

¹Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Reproductive biomedicine online

|January 20, 2024

概括

在植入前遗传测试周期中,在体外成熟的I元期卵子中的胚胎囊与在体内成熟的卵子相比,显示出类似的胚胎转移可用率. 这一发现支持它们在辅助生殖技术中的价值,当可行的胚胎有限时.

科学领域:

生殖科学生殖科学
胚胎学胚胎学
遗传学是一个遗传学.

背景情况:

卵细胞成熟对于成功受精和胚胎发育至关重要.
在体外成熟 (IVM) 为卵细胞提供了在体内成熟 (IVM) 的替代方案.
植入前遗传检测 (PGT) 是选择可行的胚胎进行移植的关键步骤.

研究的目的:

为了比较PGT循环中的in-vitro成熟的I (MI) 基相卵子与in-vivo成熟的卵子中可用的胚芽细胞的比率.
评估IVM卵细胞在辅助生殖技术 (ART) 中产生可行的胚胎的潜力.

主要方法:

一项比较研究包括来自154个PGT周期的1810个卵细胞.
卵子被分为体外成熟的MI和体外成熟的组.
后勤回归和统计测试分析了胚胎学,临床和怀孕结果.

主要成果:

在IVM MI卵子细胞和体内成熟卵子细胞之间,可用的胚胎细胞率是可比的 (调整RR为0.97).
三个活产的结果是从IVM MI卵子细胞中获得的可用芽细胞.
两组之间没有观察到可使用的胚胎细胞率的显著差异.

结论:

在体外成熟的MI卵细胞可以成功受精并发展为胚芽细胞,其可用率与体内成熟的卵细胞相似.
来自IVM MI卵细胞的芽细胞对于在ART中具有有限可行的胚胎选择的患者来说是有价值的.
在PGT和ART周期中,IVM为卵细胞成熟提供了一个可行的选择.

关键词:

胚胎囊中的胚胎细胞.欧普洛伊迪症是什么意思?在体外成熟成长.的MI卵细胞.

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