益生菌补充剂对慢性炎症过程调节在结肠直肠癌发生过程中的影响
Sabrina Karen Reis1, Eduardo Augusto Rabelo Socca2, Bianca Ribeiro de Souza3
1Faculty Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil; Laboratory of Urogenital Carcinogenesis and Immunotherapy, Department of Structural and Functional Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
在小鼠中补充益生菌可以减少结肠缩短和结肠直肠癌发生期间的炎症. 这项研究强调了益生菌.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 结肠直肠癌 (CRC) 仍然是一个重大的全球健康挑战.
- 化学诱导的致癌模型对于研究CRC的发展和治疗至关重要.
- 益生菌正在探索它们在调节肠道微生物群和炎症过程中的潜在作用.
研究的目的:
- 为了研究益生菌补充剂对大肠直肠癌发生因1,2-二甲基 (DMH) 诱导的小鼠的影响.
- 评估益生菌与5-甲 (5FU) 化疗结合对CRC的影响.
- 分析益生菌对瘤微环境的影响背后的分子机制.
主要方法:
- 由DMH诱导的结直肠癌发生的小鼠模型.
- 治疗组包括对照组,DMH,DMH+5FU化疗,DMH+益生菌和DMH+益生菌+5FU.
- 分析涉及结肠长度,组织病理学,PAS染色和炎症和扩散标记物的免疫组织化学 (例如NF-κB,Ki-67).
主要成果:
- 益生菌补充剂增加了增殖标记Ki-67.
- 益生菌可以减少体重减轻和结肠缩短.
- 益生菌通过抑制NF-κB表达和减轻粘素枯竭来调节炎症.
结论:
- 益生菌在调节与结直肠癌发生相关的炎症过程方面表现出潜力.
- 研究结果表明,益生菌可能会影响瘤微环境,需要进一步调查.
- 这项研究为探索益生菌在CRC管理中的临床应用提供了基础.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
09:01Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
