多重发病与风湿性关节炎患者的严重感染有关
Bradly A Kimbrough1, Cynthia S Crowson2, Ryan J Lennon3
1Division of Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Seminars in arthritis and rheumatism
|January 20, 2024
概括
患有某些健康状况的风湿性关节炎患者面临更高的严重感染 (SI) 风险. 识别这些并发症可以改善SI风险评估和患者护理.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 患者有严重感染 (SI) 的风险增加.
- 在RA患者中,IS的现有风险评分可能无法捕捉出导致并发症的全谱.
- 需要对在RA中与SI相关的并发症进行全面评估.
研究的目的:
- 调查各种并发症与风险之间的关联严重感染 (SI) 在类风湿性关节炎 (RA) 患者.
主要方法:
- 分析了成年RA患者 (1999-2014) 的基于人口的初始队列,并追踪到2021年.
- 伴随性疾病和SI使用经过验证的国际疾病分类 (ICD) -9和ICD-10代码来确定.
- 使用条件脆弱模型,调整人口统计,现有风险得分 (RABBIT,梅奥) 和其他因素.
主要成果:
- 该研究包括911名RA患者,其中17%的人至少有一次SI.
- 在完全调整的模型中,在55种评估的并发症中,27种并发症的SI风险显著增加.
- 严重感染风险增加了11-16%的每一个额外的伴随性疾病,突出显示了它们的累积影响.
结论:
- 多重并发症与风湿性关节炎患者严重感染的风险增加有显著的关联.
- 鉴定到的并发症可能会提高未来的SI风险评估工具对RA的准确性.
- 通过并发症概况,更好地识别高风险的RA患者,可以指导预防策略.
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