在患有复发性复发性多发性硬化症的女性中,静止时节拍血压变异性减少
Claire E Kissell1, Benjamin E Young2, Caitlin P Jarrard2
1Department of Applied Physiology and Sport Management, Southern Methodist University, Dallas, TX, USA.
Multiple sclerosis and related disorders
|January 20, 2024
概括
与健康对照组相比,患有复发性复发性多发性硬化症 (RRMS) 的女性表现出较低的血压变化. 这种降低血压变异性与RRMS患者的交感或心脏巴罗反射灵敏度的改变无关.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 自主神经系统的自主神经系统
背景情况:
- 心血管自主功能障碍在复发性复发性多发性硬化症 (RRMS) 中普遍存在.
- 交感神经系统功能障碍可能会影响RRMS女性的血压调节和变化.
- 情感控制受损可能导致静止时血压变化增加.
研究的目的:
- 为了研究与健康对照组相比,RRMS女性的血压变化.
- 为了确定是否降低了交感巴罗反射灵敏度与RRMS的女性增加了血压变化.
主要方法:
- 持续的心电图和鼓动到鼓动的血压记录在躺着休息期间.
- 在参与者的子集中测量肌肉交感神经活动 (MSNA).
- 使用已确定的方法量化同情心和心脏巴罗反射灵敏度.
主要成果:
- 患有RRMS的女性的血压变化 (标准偏差和四分位数范围降低) 比健康对照显著较低.
- 在休息时的平均动脉压,静脉血压,透气血压或MSNA之间没有观察到显著的差异.
- 在RRMS患者和对照人群中,交感和心脏巴罗反射灵敏度相似,与血压变化无关.
结论:
- 患有RRMS的女性表现出降低的,而不是增加的,节拍对节拍血压变化.
- 在RRMS中观察到的血压变异性降低不能归因于同情或心脏巴罗反射灵敏度的变化.
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