大脑协作激活的动态重新配置表明,潜在的工作记忆与临床无损的老年人认知衰退相关
Linling Li1, Zaili Chen1,2, Li Zhang1
1Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, International Health Science Innovation Center, Shenzhen University Medical School, Shenzhen University, 1066 Xueyuan Avenue, Nanshan District, Shenzhen, 518055, China.
Cerebral cortex (New York, N.Y. : 1991)
|January 20, 2024
概括
面临认知能力下降风险的老年人在工作记忆任务中显示大脑灵活性降低. 这表明神经可塑性受损,可能有助于早期识别需要干预的个人.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 老年学是一门学科.
背景情况:
- 工作记忆 (WM) 障碍在轻度认知衰退和有风险的老年人中很常见.
- 了解风险人群中WM神经特征对于早期干预至关重要.
- WM依赖于动态的前对对脑活动,但其在认知衰退期间的重新配置尚不清楚.
研究的目的:
- 在老年人中调查WM任务期间大脑协作激活状态的动态重新配置.
- 为了确定认知衰退是否与WM挑战期间大脑网络灵活性改变有关.
主要方法:
- 47名老年人接受了认知评估 (蒙特利尔认知评估).
- 在WM任务期间,使用基于图形的时间框架模块化分析了大脑协作激活的时间动态.
- 识别了经常出现的大脑状态,包括任务积极 (面对对象) 和任务负面 (默认模式网络) 状态.
主要成果:
- 增加WM负载增加了前端对等网络的灵活性.
- 认知能力下降与减少神经可塑性变化相关,以应对增加的任务需求.
- 确定了不同的任务积极和任务消极的大脑状态.
结论:
- 老年人的认知能力下降与工作记忆任务期间大脑网络适应能力的降低有关.
- 这些发现突出了异常的大脑重构作为潜在的生物标志物,用于早期识别有风险的个体.
- 这项研究促进了对与年龄相关的认知变化背后的神经机制的理解.
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