巨细胞动脉炎的视觉表现:从ARTESER注册表中识别风险因素
Juan Molina-Collada1, Marta Domínguez-Álvaro2, Rafael B Melero-González3
1Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Rheumatology (Oxford, England)
|January 20, 2024
概括
巨细胞动脉炎 (GCA) 的视觉表现影响了三分之一的患者. 高龄和关预测视觉问题,而多肌痛风湿症,发烧和高ESR降低了风险.
科学领域:
- 类风湿病学 类风湿病学
- 眼科医生 眼科 眼科
- 血管医学 血管医学
背景情况:
- 巨细胞动脉炎 (GCA) 是一种全身性血管炎,主要影响大和中型动脉.
- 视觉表现是GCA的严重并发症,可能导致不可逆转的视力丧失.
- 了解视觉参与的流行和预测因素对于及时诊断和管理至关重要.
研究的目的:
- 为了确定GCA患者的大队伍中视觉表现的流行率.
- 确定预测诊断时视觉参与的人口,临床和实验室因素.
- 为临床实践提供有关GCA视觉并发症风险分层的信息.
主要方法:
- 对ARTESER注册表的分析,这是西班牙的多中心注册表,其中包括2013年6月至2019年3月期间诊断的GCA患者.
- 收集包括人口统计,临床特征,实验室结果和成像发现在内的综合数据.
- 双变量和多变量逻辑回归分析以确定视觉表现的预测因素.
主要成果:
- 在1636名GCA患者中,599人 (36.6%) 呈现出视觉表现.
- 前面缺血性视神经病变是最常见的眼部并发症 (45.7%).
- 视觉参与的独立预测因素包括年龄较大和关节音. 多肌痛风湿,发烧,症状持续时间较长,ESR较高与风险降低有关.
结论:
- 大约三分之一的GCA患者在诊断时会出现视觉表现.
- 老年和关节音是视觉并发症的重要危险因素.
- 某些临床特征和实验室标记可能表明GCA视觉参与的风险较低.
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