分化高度甲状腺癌:诊断考虑和临床特征
I Tondi Resta1, M A Gubbiotti2, K T Montone1
1Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Human pathology
|January 20, 2024
概括
分化高度甲状腺癌 (DHGTCs) 是一种侵袭性,罕见的瘤. 我们的研究描述了它们的特征,强调了需要仔细评估甲状腺瘤的复发和预后的需要.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 分化高度甲状腺癌 (DHGTCs) 是一个新的诊断实体,在2022年世界卫生组织分类中引入.
- 关于DHGTCs的文献有限,需要进一步的案例研究和表征.
研究的目的:
- 描述DHGTCs的临床病理特征.
- 为了评估患者的结果和治疗反应在一个队列的DHGTC病例.
- 为了解这种罕见的甲状腺恶性瘤做出贡献.
主要方法:
- 在2012-2022年间诊断的32例DHGTC病例的回顾性审查.
- 对细胞学,组织学,免疫组织化学 (包括Ki67),治疗和结果数据的分析.
- 使用PubMed和Embase对DHGTC (2013-2023) 的系统文献综述.
主要成果:
- 该队列包括32例DHGTC病例,平均年龄为52.6岁,男性:女性比例为1.3:1.
- 乳头甲状腺癌是最常见的亚型 (87.5%). 攻击性特征包括甲状腺外延伸 (53%),血管侵入 (66%) 和淋巴结转移 (31%).
- 平均Ki67增殖指数为5.6%,非死核性病变中的中位数线粒细胞计数为5.5每2mm2.
结论:
- DHGTCs是罕见但具有攻击性的甲状腺瘤.
- 准确评估DHGTCs对于确定预后和管理潜在的复发至关重要.
- 需要进一步的研究,以充分了解DHGTCs的行为和最佳管理.
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