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Updated: Jul 5, 2025

Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
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人类星球细胞中的β-粉样蛋白沉积物含有截断和高度耐药的蛋白质形式

C Beretta1, E Svensson2, A Dakhel1

  • 1Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, SE-752 37 Uppsala, Sweden.

Molecular and cellular neurosciences
|January 20, 2024
PubMed
概括

星球细胞在阿尔茨海默病 (AD) 中将β-粉样蛋白 (Aβ) 内化,但不是降解它,而是修改并释放致病性Aβ片段,促进疾病传播.

关键词:
聚合物 聚合物 聚合物阿尔茨海默病的疾病阿尔茨海默病的疾病.粉样蛋白β 粉样蛋白β星球细胞是星球细胞.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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