从可注射HA水凝植入物中双相释放贝他他,用于缓解腰椎间盘带诱导的坐骨髓炎
Lunhao Chen1, Chao Jiang1, Qian Xu2
1Spine Lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Acta biomaterialia
|January 20, 2024
概括
一种新的 hialuronic 酸水凝提供持续的外腔内皮类固醇注射,有效治疗从腰椎间盘的坐骨神经炎超过10天. 这种注射系统为传统治疗提供了有希望的替代方案,减少了重复手术的需要.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 神经科学是一个神经科学.
背景情况:
- 腰椎间盘 (LDH) 导致坐骨神经炎,通常用外围注射类固醇注射 (ESI) 治疗.
- 目前的ESI治疗有效期很短,需要频繁重复注射.
- 开发持续释放ESI系统对于改善LDH的临床管理至关重要.
研究的目的:
- 开发一种可注射的基于氨酸 (HA) 的水凝,用于持续的外周药物输送.
- 在LDH的动物模型中评估载有甲二 propionate (BD) 和甲21-二 (BP) (BD/BP@HA) 的HA水凝的疗效.
- 评估BD/BP@HA在治疗LDH诱导的坐骨髓炎的临床转化中的潜力.
主要方法:
- 制造可注射的HA水凝,使用乙烯点击化学,用于双相药物释放.
- 在体外和体内评估水凝生物相容性,生物降解性和药物释放动力学.
- 在小鼠LDH模型中通过监测核因子kappa-B (NF-κB) 途径和免疫细胞激活 (巨细胞,微质细胞) 来评估抗炎作用.
主要成果:
- 该BD/BP@HA水凝植入物证明了与神经元组织的生物相容性和生物降解性.
- 从水凝中持续释放贝他美沙有效抑制了急性和慢性神经炎症.
- 在小鼠体外注射BD/BP@HA,通过抑制神经炎症,在10天以上的时间内减轻了LDH诱导的坐骨炎.
结论:
- 开发的HA水凝是持续药物输送的可行平台,为 sciatica提供长时间的治疗效果.
- 与传统的ESI相比,BD/BP@HA水凝通过抑制神经炎症,提供了优越和持续的坐骨髓炎缓解.
- 这种可注射的HA水凝系统在治疗LDH诱导的坐骨科炎方面显示出显著的临床转化潜力.
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