补充omega-3多不和脂肪酸可以改善首次诊断的抑郁症患者的记忆力:随机对照试验数据的二次分析
Ying Xue1, Lu Wang2, Ting Liu1
1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Journal of affective disorders
|January 20, 2024
概括
欧米茄-3脂肪酸 (n-3PUFA) 在患有重度抑郁症的患者中显示出对即时记忆的小但显著改善. 抗抑郁药治疗也改善了这些患者的整体认知功能.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 营养科学 营养科学
背景情况:
- 大型抑郁症 (MDD) 经常涉及认知障碍.
- 低水平的欧米茄-3多不和脂肪酸 (n-3PUFA) 与抑郁症和认知功能障碍的风险增加有关.
- 之前的研究表明,n-3PUFA补充剂可以改善MDD患者的焦虑.
研究的目的:
- 调查n-3PUFA补充剂对患有严重抑郁症患者认知障碍的有效性.
- 基于先前的研究表明,n-3PUFA有益于MDD中的焦虑症状.
主要方法:
- 一项为期12周的随机对照试验,涉及72名先前未服用药物,首次诊断患有抑郁症的门诊患者,接受了venlafaxine治疗.
- 参与者每天补充2.4g/dn-3PUFA (鱼油) 或安慰剂.
- 认知功能通过使用可重复电池评估神经心理状态 (RBANS) 随时间推移的得分来评估.
主要成果:
- 无论是n-3PUFA还是安慰剂组,在第4周和第12周,即时记忆,延迟记忆和总RBANS得分均从基线显著改善.
- 在第12周,注意力分数在两组都得到了改善.
- 与安慰剂组相比,n-3PUFA组在第4周和第12周显示出立即记忆的统计学上显著改善 (p <0.05).
结论:
- 补充omega-3多不和脂肪酸 (n-3PUFAs) 在新诊断的,从未服用过药物的抑郁症患者中提供了适度但统计学上显著的立即记忆增强.
- 标准抗抑郁药治疗同时导致研究参与者认知功能显著改善.
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