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Updated: Jul 5, 2025

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
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基于生理学的药理动力学建模,以预测孕期孕产妇的药理动力学和胎儿对卡巴马西平的暴露

Yuying Chen1, Meng Ke1, Weipeng Fang1

  • 1Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, 20 Cha Zhong M. Rd, Fuzhou 350005, People's Republic of China; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|January 20, 2024
PubMed
概括

在怀孕期间使用卡巴马齐平的生理学基础的药理动力学 (PBPK) 模型显示,怀孕期间药物度下降. 建议在第一,第二和第三季度分别调整1.4x,1.8x和2.1x的剂量.

关键词:
卡巴马西平是一种碳化合物.卡巴马泽-10,11-环氧化物胎儿 胎儿 胎儿 胎儿 胎儿基于生理学的药物动力学模型.怀孕 怀孕 怀孕 怀孕

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