针对COVID-19的小分子抗病毒疗法:系统性审查和网络元分析
Bei Zheng1, Qinqin Zhao1, Wenjuan Yang1
1Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China; Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
International journal of antimicrobial agents
|January 20, 2024
概括
小分子抗病毒药物在治疗COVID-19方面表现有前途. 普洛克苏胺有效降低死亡率和改善恢复,而其他抗病毒药物如Triazavirin和VV116有助于病毒清除.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 病毒学 病毒学
背景情况:
- 新型冠状病毒疾病2019 (COVID-19) 构成了全球重大健康挑战.
- 有效的抗病毒疗法对于管理COVID-19和减少疾病负担至关重要.
研究的目的:
- 系统评估各种小分子抗病毒药物在COVID-19治疗中的有效性和安全性.
- 为了比较不同患者群体和疾病严重程度的不同抗病毒药物的有效性.
主要方法:
- 在七个数据库中进行了全面的文献搜索,截至2023年6月1日.
- 偏差风险评估是使用Cochrane风险偏差工具和纽卡斯尔太华尺度进行的.
主要成果:
- 分析了160项涉及933,409名患者的研究.
- 普洛克苏胺显著降低了死亡率,住院和不良事件,并改善了临床康复.
- 特里亚扎维林加速病毒清除,而莱里特里尔维尔,VV116和莫尔努皮拉维尔在病毒清除和氧气支持方面显示出特定的好处.
结论:
- 小分子抗病毒药物包括普罗克萨尔胺,尼尔马特雷尔维尔/里托纳维尔,特里亚扎维林,阿兹武丁,莫尔努皮拉维尔和VV116在治疗COVID-19中显示出显著的益处.
- 对于simnotrelvir/ritonavir和leritrelvir需要进一步的数据,但整体的安全性概况是可以接受的.
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