原生心脏门的新血管化,以及与其病史学,临床和放射学特征的相关性
Simona Pichler Sekulic1, Miroslav Sekulic1
1Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
概括
新血管化,即新血管的生长,在受损的心脏门中很常见,影响了超过一半的病例. 这一发现与门加厚,化和各种患者健康状况有关.
科学领域:
- 心血管病理学心血管病理学
- 组织病理学 组织病理学
- 血管生物学 血管生物学
背景情况:
- 慢性损伤导致本地心脏门重塑,包括加厚,化和新血管化,导致功能异常.
- 新血管化是慢性心脏门疾病病理过程中的一个关键特征.
研究的目的:
- 在本地心脏门中描述新血管化的患病率和体病学特征.
- 为了将新血管化与临床发现和其他组织病理学变化的相关性.
主要方法:
- 对所有类型的1246个原生心脏门进行了回顾性审查.
- 新血管化与组织病理学特征,临床数据和心声回声学发现的相关性.
主要成果:
- 新血管化在55.5%的病例中存在,最常见的是大动脉.
- 新血管化与患者年龄增加,体重指数,冠状动脉疾病,脂质不良,糖尿病,类风湿性发烧和恶性瘤相关.
- 增加的门加厚,化和狭窄与较高的新血管化率有关,而排泄显示出相反的关系.
结论:
- 新血管化是慢性疾病影响的本地心脏门中经常出现的组织病理学发现.
- 它代表了对慢性损伤的结构改造的一个组成部分,并与特定的临床和病理因素有关.
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