在老鼠中,慢性睡眠不足通过氧化损伤损害视觉功能
Liying Tang1, Houjian Zhang2, Yi Liao3
1Xiamen University-affiliated Xiamen Eye Center, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, China; Department of Ophthalmology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
The American journal of pathology
|January 20, 2024
概括
慢性睡眠不足会损害小鼠的视网膜功能和线粒体. 抗氧化剂补充剂,如α-酸和N-乙半氨酸,在保护眼睛健康免受睡眠损失方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 细胞生物学 细胞生物学
背景情况:
- 睡眠不足 (SD) 是一个重要的公共卫生问题,已知对神经系统有负面影响.
- 视网膜是中枢神经系统的一部分,容易受到神经损伤,但SD对视网膜健康的影响尚不清楚.
研究的目的:
- 研究慢性睡眠不足对视网膜结构和功能的影响.
- 阐明睡眠丧失引起的视网膜损伤的潜在机制.
- 评估抗氧化剂对睡眠剥夺引起的视网膜功能障碍的潜在治疗作用.
主要方法:
- 在4个月内建立了一种慢性睡眠剥夺小鼠模型.
- 评估视觉功能,并使用传输电子显微镜检查视网膜形态.
- 分析了线粒体完整性,蛋白质水平和氧化应激标志物.
- 评估了抗氧化剂补充剂 (α-酸和N-乙-氨酸) 的效果.
主要成果:
- 慢性睡眠不足导致视觉功能下降,但视网膜没有显著的粗形态变化.
- 超结构分析揭示了线粒体损伤和视网膜中线粒体蛋白质水平的降低.
- 睡眠不足导致氧化应激,在休息后可逆.
- 抗氧化剂治疗减少了活性氧物种,修复了线粒体,改善了视网膜功能.
结论:
- 睡眠对于保持视网膜完整性和健康至关重要.
- 线粒体功能障碍和氧化应激是将睡眠剥夺与视网膜损伤联系起来的关键机制.
- 抗氧化剂补充剂是一种可行的策略,可以减轻睡眠丧失对视网膜的不良影响.
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