在成年大脑中,微质细胞调节神经回路和行为
Shunyi Zhao1, Anthony D Umpierre2, Long-Jun Wu3
1Department of Neurology, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.
Trends in neurosciences
|January 20, 2024
概括
恒常性微质细胞通过直接的突触相互作用来调节神经元活动和行为. 在中枢神经系统 (CNS) 中调节这些免疫细胞会影响神经回路,并导致各种行为结果.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 微质细胞是中枢神经系统 (CNS) 中的主要免疫细胞.
- 它们在神经系统疾病的炎症和修复中都起作用.
- 新出现的证据表明,恒常性微质细胞调节神经元活动,突触功能和行为.
研究的目的:
- 审查微质细胞如何通过突触相互作用感知和调节神经元活动.
- 讨论微质细胞与神经网络和行为的直接参与.
- 探索调节微质对神经回路和行为的影响.
主要方法:
- 对微质神经元相互作用的当前文献的综述.
- 讨论用于调节成年神经回路中的微质活动的光遗传和化学遗传技术.
- 对检查微质操纵行为后果的研究进行分析.
主要成果:
- 微质细胞直接与突触相互作用,影响神经元活动.
- 在不同中枢神经系统区域中微质细胞的调节会导致各种行为变化.
- 微质-神经元相互作用的空间异质性被认为是关键因素.
结论:
- 微质是神经回路的组成部分,积极调节神经元功能和行为.
- 向微质细胞为理解和治疗神经系统疾病提供了潜在的潜力.
- 对微质神经元相互作用的空间动态进行进一步的研究至关重要.
相关概念视频
Glial Cells
87.2K
Overview
87.2K
Neuroplasticity
363
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
363
Neurogenesis and Regeneration of Nervous Tissue
796
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
796
Nervous Tissue: Glial Cells
3.0K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
3.0K


