纵向海马子场的发展与年轻人的精神病经历有关
Aisling O'Neill1,2,3, Niamh Dooley4,5, Darren Roddy4,5
1Department of Psychology, St Patrick's Mental Health Services, Dublin, Ireland. aoneill@rcsi.com.
Translational psychiatry
|January 20, 2024
概括
这项研究检查了患有精神病经历 (PE) 的青少年的海马子场体积. 虽然初步发现表明存在差异,但在PE患者中,经过校正后,没有发现海马子的显著异常.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 海马体积减小与精神病谱系障碍有关.
- 特定的海马子场缺陷,特别是CA1,与精神病神经病理生理学有关.
- 在青少年中调查下值精神病体验 (PE) 提供了对早期神经机制的洞察力.
研究的目的:
- 为了研究带有和没有PE的青少年海马体子场体积的纵向变化.
- 确定与PE的发展或存在相关的特定子领域异常.
- 了解青春期低值精神病体验的神经基础.
主要方法:
- 78名青少年 (在基线时11-13岁) 的纵向神经影像 (超过6岁).
- 根据专家的共识,将参与者分为PE组 (33) 和控制组 (45).
- 线性混合效应分析双边海马子场体积 (CA1,CA2/3,CA4/DG,前,下).
主要成果:
- 未经纠正的分析表明,对右CA2和CA2/3子字段的PE组的控制量增加和减少.
- 与对照组相比,未经纠正的发现还显示PE组的右脑垂体和左脑前垂体体积减少.
- 重要的是,这些观察到的差异中没有一个在多次比较的统计纠正中幸存下来.
结论:
- 尽管在特定海马体子区域的初始未经校正的体积差异,但在PE青少年的校正后,没有证实有重大异常.
- 这些发现表明,微妙或短暂的海马子场变化可能不是这个年龄组中亚值精神病体验的强有力的生物标志物.
- 需要进一步的研究来阐明海马结构和精神病体验的发展之间的复杂关系.
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